Search Result

Search Results for " cyclin-dependent kinase 7 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9615	CK7		CDK
	CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.		CDK
T11929	M2N12		Phosphatase
	M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhi...		Phosphatase
T19913	CKI-7	CKI 7 2HCl,CKI-7 dihydrochloride,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl	ROCK , SGK , Casein Kinase , CDK , S6 Kinase
	CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.		ROCK , SGK , Casein Kinase , CDK , S6 Kinase
T9078	LY3405105	1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester	CDK
	LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) is a novel CDK7 inhibitors.		CDK
T7698	BS194		CDK
	BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.		CDK
T27805	LDC3140	LDC 3140,LDC-3140,LDC043140
	LDC3140 is a potent inhibitor of Cyclin-dependent kinase 7 (CDK7).
T69209	ZK-304709
	ZK-304709 is a potent multi-target tumor growth inhibitor with IC50 = nanomolar inhibitory activity to cyclin-dependent kinases 1, 2, 4, 7 and 9, as well as vascular endothelial growth factor receptor tyrosine kinase 1-3...
T39372	CDK7-IN-1	CDK7-IN-1
	CDK7-IN-1 is an analog derived from YKL-5-124 and functions as an inhibitor of cyclin-dependent kinase 7 (cdk7). It exhibits strong inhibitory activity, with an IC50 value of less than 100 nM (WO 2016105528 A2, Compound ...
T74853	PROTAC CDK9 degrader-7
	PROTAC CDK9 degrader-7 is a proteolysis-targeting chimera (PROTAC) specifically designed to target and mediate the degradation of Cyclin-Dependent Kinase 9 (CDK9) through the proteasome pathway [1].
T39943	CDK7-IN-6	CDK7-IN-6
	CDK7-IN-6 is a highly effective and specific inhibitor (IC50 ≤100 nM) of cyclin-dependent kinase 7 (CDK7). It showcases remarkable selectivity, with more than a 200-fold preference for CDK7 over CDK1, CDK2, and CDK5. Thi...
T62354	CDK8-IN-7
	CDK8-IN-7 (compound 12) is a potent and selective inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 3.5 nM). CDK8-IN-7 has shown potential for AML-cancer research.
T62695	GFB-12811
	GFB-12811 is a highly selective and orally active inhibitor of cyclin-dependent kinase 5 (CDK5), exhibiting an inhibitory concentration (IC50) of 2.3 nM. It demonstrates notable specificity, with minimal activity against...
T73163	CDK7-IN-20
	CDK7-IN-20 is a potent, selective, and irreversible inhibitor of Cyclin-Dependent Kinase 7 (CDK7) with an IC50 value of 4 nM, exhibiting over 206-fold selectivity against related kinases CDK1, CDK2, CDK3, CDK5, CDK6, CDK...
T36844	Inostamycin A
	Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes)...

Compounds

Synonym: CKI 7 2HCl,CKI-7 dihydrochloride,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl

Target: ROCK, SGK, Casein Kinase, CDK, S6 Kinase

LY3405105

T9078

Synonym: 1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester

Synonym: LDC 3140,LDC-3140,LDC043140

PROTAC CDK9 degrader-7

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04449	CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 118.8 kDa and the accession number is P50613&P51946&P51948.
TMPH-01173	CDK7 Protein, Human, Recombinant	Human	E. coli
	CDK7 Protein, Human, Recombinant is expressed in E. coli.
TMPH-01172	CDK7 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CDK7 Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPY-02921	CDK2AP2 Protein, Human, Recombinant (His)	Human	E. coli
	CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including...
TMPY-06036	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7.
TMPK-01371	IGFBP-7 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 ...
TMPK-00394	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num...
TMPK-00395	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
TMPK-00828	Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire...
TMPK-00392	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in num...
TMPK-00393	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
TMPY-06035	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7.